Bilirubin Auto Direct FS
Product Number : 1 0821
Bilirubin is a breakdown product of hemoglobin. Free, unconjugated bilirubin is extremely apolar and nearly insoluble in water, thus forming a complex with albumin for the transport in the blood from the spleen to the liver. In the liver, bilirubin is conjugated with glucuronic acid, and the resulting water-soluble bilirubin glucuronic acid is excreted via the bile ducts.
Hyperbilirubinemia can be caused by increased bilirubin production due to hemolysis (pre-hepatic jaundice), parenchymal damages of the liver (intra-hepatic jaundice) or by occlusion of bile ducts (post-hepatic jaundice). A chronic congenital (predominantly unconjugated) hyperbilirubinemia called Gilbert’s syndrome is quite frequent in the population. High levels of total bilirubin are observed in 60 – 70 % of neonates due to an increased postpartum breakdown of erythrocytes and because of the delayed function of enzymes for bilirubin degradation. Common bilirubin methods detect either total bilirubin or direct bilirubin. Determinations of direct bilirubin measure mainly conjugated, water-soluble bilirubin. Unconjugated bilirubin can therefore be estimated as the difference between total bilirubin and direct bilirubin.
- Neonatal jaundice due to bile duct atresia
- Obstructive jaundice
- Ready to use reagent.
Proline Bilirubin Auto Direct FS comes in a liquid format which provides convenience for users as no reconstitution is required which helps reduce the risk of misdiagnosis.
- Open system reagent, compatible with a wide range of instruments.
Proline Bilirubin Auto Direct FS reagent is suitable for various third party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Response, TokyoBoeki, and Beckman Coulter.
- Photometric test using 2,4-dichloroaniline (DCA)
No interference: ascorbic acid 30mg/dL, bilirubin 40mg/dL, hemoglobin 500mg/dL, naproxen 1 mmol/L and lipemia up to triglycerides 1000mg/dL.
- Measurement linearity is up to 10 mg/dL, with a lower limit of detection of 0.01 mg/dL.
- TruCal U
- TruLab N
- TruLab P
|No. Catalog||R1||R2||Kit Size|
|1 0821 99 10 920||4 x 38 mL||4 x 11 mL||Proline® R-910|
|1 0821 99 10 921||4 x 23 mL||4 x 7 mL||Proline® R-910|
|Adults and Children||≤ 3.4 µmol/L|
Each laboratory should check if the reference ranges are transferable to its own patient population and determine its own reference ranges if necessary.