Description

Creatinine is a waste product excreted by the kidneys mainly by glomerular filtration. The concentration of creatinine in the plasma of a healthy individual is fairly constant, independent of water intake, exercise, and rate of urine production. Therefore, increased plasma creatinine values always indicate decreased excretion, i.e. impaired kidney function. The creatinine clearance enables a quite good estimation of the glomerular filtration rate (GFR) which allows better detection of kidney diseases and monitoring of renal function. For this purpose, creatinine is measured simultaneously in serum and urine collected over a defined time period.

Increased in

• Impaired kidney function. Serum creatinine is a more specific indicator of kidney disease than serum urea.
• Urinary tract obstruction
  Diabetes
• Rhabdomyolysis
• Acromegaly
• Nephritis

Decreased in

• Decreased muscle mass (eg muscular dystrophy, myasthenia gravis)

Features

• Ready to use reagent.
  Proline Creatinine FS comes in a liquid format which provides convenience for users as no reconstitution is required which helps reduce the risk of misdiagnosis.
• Open system reagent, compatible with a wide range of instruments.
  Proline Creatinine FS reagent is suitable for various third party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Response, TokyoBoeki, and Beckman Coulter.

Specification

• Kinetic test without deproteinization according to the Jaffe method.
• No interference: ascorbic acid 30mg/dL, bilirubin from 4mg/dL, and hemoglobin 500mg/dL, and triglyceride lipemia 2000mg/dL
• Measurement linearity reached 5 mg/dL (18 – 1330 mol/L), with a lower limit of detection 0.2 mg/dL (17.7 mol/L)

Calibrator

• Creatinine Standard FS
• TruCal U

Control

• TruLab N
• TruLab P

Kit Lines